Beilstein J. Org. Chem.2020,16, 638–644, doi:10.3762/bjoc.16.60
combined strong Brønsted acid catalytic platform consisting of a chiral disulfonimide and 2-carboxyphenylboronic acid. The optical purity of the obtained CF2-substituted aziridines could be further improved by a practical dissolution–filtration procedure.
Keywords: aziridines; chiraldisulfonimides
limited Brønsted acidity of chiral phosphoric acids. Bearing this in mind, we then turned our attention to chiraldisulfonimides developed by List, which have been established as a unique type of stronger Brønsted acids [45]. Putting it into practice, a range of BINOL-derived disulfonimides was used as
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Graphical Abstract
Scheme 1:
Preparation of chiral aziridines from fluorinated diazo reagents.